Bioreactor
& Bioprocess Fluid Dynamics
Most biological
processes carried out in industry are influenced by the relationship
between the biological entities of interest and the fluid dynamic
regime imposed on them. In bioreactors, for example, fluid dynamics,
oxygen transfer and mechanical stresses affect the operation of
processes as diverse as animal cell culture and mycelial fermentation.
In biotransformations, the stability of support materials for cell
and enzyme immobilisation is highly dependent on the fluid dynamic
regime whilst phase inversion in aqueous/organic systems is influenced
considerably by the shear applied to the mixture. In the downstream
processing area, fluid dynamics considerations are of importance
in the design of operations for cell disruption, recovery of intracellular
components, membrane separations and flocculation.
The efficiency
of many bioprocesses used in environmental engineering and water
treatment depends on fluid dynamics. The food and drink industry
has many examples of important and difficult mixing and rheological
problems. In the area of new biological advances, the handling of
very large biological molecules (such as DNA for use in gene therapies)
on a process scale presents new challenges since these entities
can be both very shear sensitive and highly fouling in conventional
equipment. Ultimately, the success of a bioprocess at any scale
is dependent on bringing together, economically, a suitably succession
of fluid dynamic environments for each stage of operation.
Conference
Proceedings
The Conference
Proceedings are now available from Mrs
Marian Rolfe containing the following papers.
Stirred
Bioreactor Systems
The effects of
mixing modes on recovery of Xanthan Gum by precipitation
XM Zhao, HW Ma, X Li, R Ban; Tianzin University, PR China
Mixing in fungal (A. niger) fermentations using dissimilar impeller
systems
W Bujalski, P W Cox, C R Thomas, A W Nienow, University of Birmingham,
UK;
M A Priede, Experimental Plant of Biochemical Preparations, Latvia;
U E Viesturs, State Institute of Wood Chemistry, Latvia
Mass Transfer Studies on Cynara Cardunculus L & Centaurea Calcitrapa
Suspension Cultures. The Influence of Oxygen - Vectors
M E Lima Costa, Universidadé do Algarve, S Raposa, A Clemente,
INETI-IBQTA; M S S Pais, Faculdade de Ciências de Lisboa; J M S Cabral,
Instituto Superior Técnico, Portugal
Impact of mixing and polymer addition on the flocculation of high-concentration
cell debris
S Stocks, C M McFarlane, University of Birmingham; D MacKay, BIOSEP,
AEA Technology UK
Food
Processing
Effect of impeller
geometry on the production of aroma compounds by Trichoderma Harzianum
R D Godoy-Silva, L Serrano-Carreón, E Galindo, Instituto de Biotecnolgía;
G Ascanio, Centro de Instrumentos, Mexico
Ultrafiltration of fruit pulps
F Chiampo, R Conti, Politecnico di Torino, A Occelli, Allione SpA
Industria Alimentare, Italy
The effect of the fluid dynamics of yoghurt on the final product quality
J Otten, Z E H Otten, C P Verheij, F D Zoet, H J L J van der Linden,
Institute for Dairy Research (NIZO), The Netherlands
Non-Stirred
Bioreactors
Fabrication and
characterisation of Agar/Zircon sand composite absorbents for protein
recovery in liquid fluidized beds
J Zhu, Chengdu University of Science and Technology, China; A Lyddiatt,
A W Pacek, A W Nienow, University of Birmingham, UK
High density culture of hairy roots with a radial flow reactor
S Tone, M Kino-oka, Y Hitaka, M Taya,Osaka University, Japan
Physical
Aspects Of Non-Stirred Bioreactors
Airlift reactors
for wastewater treatment: Enhancing flexibility through improved turndown
ratio
Y Chisti, F Wenge, M Moo-Young, University of Waterloo, Canada
New experimental results on the mass transfer from single oxygen bubbles
into water as the liquid phase
T Paaschen, A Lübbert, Martin Luther Universität, Germany
Waste water treatment using a plunging jet oxygenator issuing into
a downflowing liquid
G D Moppett, C D Rielly, J F Davidson, University of Cambridge,
UK
A plunging jet sparger for injecting gas into downflowing liquids
R B Thorpe, B Jemsby, R Fairhurst, Y H Lee, D M Scott, University
of Cambridge, UK
The revolving drum bioreactor: a new development for bio-hydrometallurgical
processing
G Loi, P Trois, G Rossi, University of Cagliari, Italy
Cell
Damage In Bioreactors
The Effect of Solids
Suspension on Cell Damage
N J Scholtz, S T L Harrison, A B Pandit, University of Capetown,
South Africa
A Population Balance Model for Fragmentation of Filamentous Microorganisms
P Jüsten, G C Paul, A W Nienow, C R Thomas, University of Birmingham,
UK
Computational
Fluid Dynamics (CFD)
Computational fluid
dynamics to assess the release of microorganisms from bioprocesses
P A Agutter, N J Titchener-Hooker, M K Turner, University College
London, UK; A D Buss, Glaxo Wellcome Research & Development, UK
CFD modelling and experimental study of a new circulating bed bioreactor
performances
V Lazarova, Z Doquang, CIRSEE, Lyonnaise des Eaux, France; A Cockx,
G Hebrard, D Bastoul, A Couvert, M Roustan, A Liné, LIPE, INSA-GPI,
France
Large
Scale Industrial Bioreactors
k1a characterization
of industrial fermentors
A G Pedersen, Novo Nordisk A/S, Denmark
Mixing of Liquid phase in large vessels equipped with multiple impellers
M Whitton, Courtaulds Coatings (Holdings) Ltd; S Cropper, G Özcan-Taskin,
BHR Group Limited, UK
Rheology, mixing time and regime analysis for a production-scale Aspergillus
Oryzae fermentation
M R Marten, K S Wenger, S A Khan, Novo Nordisk Biochem North America,
USA
Membranes
Influence of shear
stresses on biokinetics and suspension filtrability in a membrane
bioreactor (MBR)
C Wisniewski, A Grasmick, Université de Montpellier II, France
Liquid membrane separation of Cephalosporin-C from culture broth
G C Sahoo, R L Bezbaruah, M K Roy, N N Dutta, Regional Research
Laboratory, India
Membrane bioreactors in fermentation process: Two-phase flow may be
a solution to enhance crossflow filtration flux
C Lafforgue, O Pichot, M Mercier, C Fonade, G Goma, Institut National
des Sciences Appliquées, France
Physical
Aspects of Stirred Bioreactors
Gas hod-up and
gas-liquid mass transfer in three-phase stirred tank bioreactors with
simulated Non-Newtonian fermentation broths
Y Kawase, K Shimizu, S Takada, Toyo University, Japan
Spatial characteristics of oxygen transfer in a dual impeller agitated
aerated tank
J M T Vasconcelos, W Bujalski, Instituto Superior Tecnico (Lisboa),
Portugal; A W Nienow, SS Alves, University of Birmingham, UK
Measurement of sound in bioreactors to estimate bubble size distributions
J W R Boyd, J Varley, Reading University, UK
Hydrodynamics in three-phase stirred tank bioreactors: simulated Newtonian
and Non-Newtonian media
Y Kawase, K Shimizu, H Miura, Toyo University, N Dohi, N Itano,
Mitsubishi Chemical Corporation, Japan
CFD
Workshop
Guest Speaker:
Current status in CFD, Professor H van den Akker, TU Delft, The
Netherlands
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Copyright BHR Group Limited 2003. All rights reserved.